80% of all bacterial infections are associated with so called bio-film resistance. Bio-film resistance is an often overlooked problem. Traditional antibiotics are known to be inactive in bio-film protected bacteria. Bio-film is an extracellular polymeric substance, which is also referred to as slime (although not everything described as slime is a biofilm). It is generally composed of extracellular DNA, proteins, and polysaccharides. Bio-films may form on living or non-living surfaces and can be prevalent in natural, industrial and hospital settings.
A significant bottleneck that limits the efficacy of traditional antibiotics is the slow growth rate and low metabolic activity of bacteria in such a ‘biofilm protected’ community of bacteria. The use of SAAPs to inhibit bio-film formation is an attractive therapeutic approach, as SAAPs are highly active against bio-films protected bacteria.
In fact, due to the mechanism of action of SAAPs, which relies on their ability to permeabilize and to form pores within the cytoplasmic membranes, they have a high potential to act also on slow growing or non-growing bacteria, even if they reside in bio-films.